This season, Manchester United left-back Luke Shaw was the only player to start all 28 Premier League matches, but that record is now at risk of ending. He was substituted due to injury halfway through the first half against Crystal Palace.

Luke Shaw clashed feet with Crystal Palace's right wing-back Daniel Muñoz in the penalty area, having his foot stepped on. Usually this is just a bruising injury, but the 30-year-old 'English Carlos' remained sitting on the ground and did not get up. After the team doctor's examination, Luke Shaw walked off the pitch and returned to the dressing room for treatment, with Mazraoui taking his place at left-back.
Carrick stated after the match that Luke Shaw was substituted due to illness. "He was just feeling unwell; he had been sick before. We'll see how he recovers, hopefully it's not too serious."
However, Italian transfer expert Fabrizio Romano reported that Luke Shaw was indeed injured and requires further assessment. Romano said: "Luke Shaw was substituted due to injury and will be evaluated by Manchester United's medical staff."
British media report that Luke Shaw's condition cannot be determined until further examination. If Muñoz's seemingly minor action caused a metatarsal injury, Shaw might require surgery and be sidelined for 6 to 12 weeks, which would completely shatter his World Cup hopes.
If it is a muscle tissue injury, he could be out for about 10 weeks, which is also not a good outcome. In the best-case scenario, Luke Shaw only has a minor bruise or tissue damage, healing in a few days or, at worst, a few weeks.

If Luke Shaw is unavailable, Mazraoui can replace him directly. The Moroccan international, though a right-back, often plays on the left. In this season's Africa Cup of Nations, he was named in the tournament's best XI as a left-back!
Another Manchester United right-back, Diogo Dalot, can also play left-back. On the bench is 26-year-old Dutch player Tyrell Malacia, a natural left-back whose only appearance this season came in the home match against Newcastle.
In any case, Luke Shaw is now doubtful for Manchester United's away match against Newcastle United, which takes place this Wednesday. But for the next home game against Aston Villa, there is a longer gap—it isn't until March 15th, giving an 11-day break after the Newcastle trip, largely because United are out of the FA Cup.
Manchester United are expected to sign a full-back this summer, most likely a left-back. Although Luke Shaw's "availability" this season seemed relatively long, his injury record is unconvincing. British media jokingly say there are three certainties in life: death, taxes, and Luke Shaw's injuries.
32-year-old Manchester United center-back Harry Maguire also appeared injured in the match against Crystal Palace, walking off the pitch limping. However, compared to Luke Shaw, Maguire is more likely to be available for the Newcastle match. Carrick said: "Both were just feeling unwell, so hopefully they'll recover soon."

Other players on Manchester United's injury list include center-backs Lisandro Martínez and Matthijs de Ligt, midfielder Mason Mount, and left-sided player Patrick Doku. Martínez and Mount are considered to have a chance of returning for the crucial top-four clash against Villa, while de Ligt and Doku will need longer recovery time.